Waching daily Nov 1 2017

Alzheimer's news: Neurodegenerative disease 'could originate OUTSIDE the brain'

Scientists believe a rogue protein strongly linked to the disorder may appear elsewhere in the body before breaking through the brains natural defences. If the theory is right, it could have huge implications for diagnosing and treating the disease.

New therapies could target the amyloid-beta protein and clear it from the body before it spreads to the brain.

The protein accumulates in sticky clumps, or plaques, in the brains of Alzheimers patients but can also be present in blood platelets, blood vessels, and muscles. In addition the precursor molecule from which it is derived can be found in several organs.

Until now there has been no clear evidence to show that amyloid-beta from outside the brain plays a role in Alzheimers. But experiments with mice indicate that it can travel through the blood stream before entering the brain and triggering the disease.

Lead scientist Professor Weihong Song, from the University of British Columbia, Canada, said: "Alzheimers disease is clearly a disease of the brain, but we need to pay attention to the whole body to understand where it comes from and how to stop it." The researchers studied surgically conjoined mice, one of which was normal and the other modified to carry a mutant human Alzheimers gene that produces high levels of amyloid-beta.

After remaining attached to their partners for a year, the normal mice developed Alzheimers disease. Their brains were infected with toxic protein that had spread from the genetically modified mice via the animals shared blood circulation, the scientists believe.

Not only did the normal mice acquire amyloid-beta plaques, they also developed another key hallmark of Alzheimers - twisted protein strands within neurons known as "tau tangles".

Other signs of Alzheimers-like damage included the loss of brain cells, inflammation and microbleeds. The ability to transmit electrical signals involved in learning and memory was impaired in the normal mice after just four months.

Prof Song pointed out that the "blood-brain barrier" - a cellular "wall" that acts like an immigration checkpoint, allowing some molecules in and not others - weakens with age.

"That might allow more amyloid-beta to infiltrate the brain, supplementing what is produced in the brain itself and accelerating the deterioration," he said. Developing effective drugs that overcome the blood-brain barrier is a challenge.

Tackling Alzheimers by targeting amyloid-beta outside the brain may be a lot easier, say the scientists. Prof Song envisioned drugs that could tag the protein biochemically to facilitate its clearance from the body by the liver and kidneys.

The research is reported in the journal Molecular Psychiatry.

Dr David Reynolds, chief scientific officer at the charity Alzheimers Research UK, said: "As with any research involving mice, the only way to know if these findings are relevant to how Alzheimers develops in people is through studies that focus on human biology.

"If these findings do prove to be relevant to people, it highlights the continued importance of developing treatments that target amyloid in the body as well as the brain." He added: "There is no suggestion from this research that Alzheimers could be spread by blood transfusions in people.

"Last year an extensive study involving 1.4 million people who were followed up for many years found no increased risk associated with receiving a transfusion from people with Alzheimers."  .

For more infomation >> Alzheimer's news: Neurodegenerative disease 'could originate OUTSIDE the brain' - Duration: 5:01.

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Selena Gomez Speaks Out About Kidney Transplant From Her Best Friend Francia Raisa | TODAY - Duration: 6:54.

For more infomation >> Selena Gomez Speaks Out About Kidney Transplant From Her Best Friend Francia Raisa | TODAY - Duration: 6:54.

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The dollhouses of death that changed forensic science - Duration: 8:16.

Something terrible happened in these dollhouses.

Maybe a suicide.

A murder.

A stabbing with an adorable knife.

These dollhouses are part of Frances Glessner Lee's Nutshell Studies of Unexplained Death,

which she made in the 1940s and early 50s.

They're in the Renwick Gallery of the Smithsonian American Art Museum

for a reason.

They're incredibly detailed —

these cans are all labeled.

Accurately.

And these dollhouses are used by law enforcement

to train and to develop analytical capabilities.

But these artful dioramas actually contain two mysteries:

What happened in these houses?

And why did Frances Glessner Lee spend her time, and part of her fortune, making them

perfect?

This is "three-room dwelling," and it's a dollhouse murder showstopper.

There are 19 of these dioramas and each one comes with a backstory, drawn from composite

real crimes.

In this one, Robert, Kate, and baby Linda Mae Judson had a nice porch where the milkman

stopped by.

They were living the American dream until the murders happened.

"As you start to sort of investigate the evidence...

the first time I approached this case, I looked at it for a couple of hours, I took tons of

pictures home and I analyzed them for hours, trying to figure this out, because it doesn't

seem like things add up.

There's a bloodstain that's in the baby's room but it's just a blood pool, and there

doesn't seem like there's any kind of trail from it, it's just sitting there.

We don't know what had happened there.

There's bloody footprints that are leading into the bedroom, the husband is lying on

the ground on some of the bed coverings, we have no idea how he died, he's covered in

blood all over his pajamas, so it's very hard to tell."

Three-room Dwelling's morbid details come from the same mind that crafted incredibly

delicate ones.

"There's this little eggbeater down under the cubbard here that I like to point out,

and this was apparently originally a solid gold charm from a charm bracelet.

The Nutshells themselves are lit as the rooms would be, the flashlight helps you find the

evidence.

There's quite a lot of evidence in these pieces that you would probably never discover

without it, so it's a fun thing to have in the exhibition, but it's also a real

training tool for really systematically looking through these pieces."

And you notice the fabric on a chair, the blocks scattered on the porch, and the blood

spattered on the baby's wall.

Because law enforcement still use these to train, it's tempting to play CSI with these

murders.

But notice that Atkinson only broke down the nutshells, she didn't didn't give away any

solutions.

That's partly because the solutions are still kept secret for those in training.

But mostly, it's because the mystery serves a purpose.

"The point of the nutshells is not to solve them.

The point is to collect detail."

Erin Bush saw the nutshells in their home before the Renwick gallery — the Maryland

Medical Examiner's office, where they're used for training investigators.

"The goal of the nutshells is to train your eye to see small, minute, seemingly insignificant

details that stand out.

So the kitchen: It's Spring, 1944 — Robin Barnes is a

housewife.

Fred Barnes, her husband finds her.

And the story is, he's out of the house to run an errand.

He comes home, he looks through the kitchen window and he sees her laying on the kitchen

floor.

He can't open the door, the door is locked from the inside, the window is locked from

the inside.

So he calls the police, the police break the door down.

So this is what we know when we arrive.

She was clearly in the middle of something.

She's clearly preparing a meal.

There's a pie in the stove, there are potatoes in the sink.

You don't commit suicide if you're in the middle of dinner.

And I think, if you look very closely at the stove, and if you can recognize a 1940s stove,

you will see that all the gas jets are on.

There are a lot of weapons in the room.

There's a rolling pin, there's an iron, there is a knife, on the chair.

It's very possible someone hit her over the head.

If you look very closely at the door, it's stuffed with newspaper.

So now we're back to suicide.

The point, of course, was to recognize these details and to teach investigators how to

recognize these details.

It was a very different way to investigate crime than they were used to."

Frances Glessner Lee was an heir to International Harvester, a company that produced farm equipment

and other machinery.

Her family made a fortune, a part of which she eventually used to fund miniature crime

scenes.

She endowed Harvard's Department of Legal Medicine, the first of its kind, and became

an honorary police captain.

Her artistic obsession helped detectives become more attentive to crime scenes, relying on

evidence instead of hunches.

"For me, as a historian, when I look at them, I don't think who did it, I think

my God why is she inventing this scene the way she's inventing it, you know, what's

in her head, and to me that's fascinating."

Lee's nutshells are as complex as the scenes they depict.

They overflow detail: the magazines crumpled on the floor; the apples that will never be

eaten; the body that will never move but is so vividly rendered that you can imagine it

once did.

"On the one hand, she was the young Frances Glessner who was this philanthropic lady who

was brought up in a fine household, and the other half of her personality was

Captain Lee, and those two things did come together sometimes."

Lee wrote a 1952 article in the Journal of Law and Criminology.

"Some years ago, the writer was greatly surprised to learn that nowhere in America

was Legal Medicine, as thus described, being taught.

The writer has for many years worked sporadically at miniatures, hence these presented themselves

as the solution."

Frances Glessner Lee died in 1962 of natural causes.

"It must be understood, these models are not 'whodunits' - they cannot be solved

merely by looking at them.

They are intended to be an exercise in observing, interpreting, evaluating and reporting-- there

is no 'solution' to be determined."

This toy's only approved for ages...dead and older.

"YEAAAAHHHHHHH!!!"

For more infomation >> The dollhouses of death that changed forensic science - Duration: 8:16.

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Big Shaq — Mans Not Hot Remix (Shaquille O' Neal Diss Track) - Duration: 3:06.

Man like Shaquille O'Neal, he thinks he's bad

He doesn't want to link me

I'm ready to link him now you understand what i'm saying

I've dealt with man like him, its like David & Goliath

You know what i'm saying? That Shaq is expired

You understand?

Your careers over, big man. You understand? There's a new man in town

Man come from the U.K mans squaddeded it up

Squaded up

You dun know

Yeh yeh

Yo!

You dun know, it's big shaq, boom

I'm not even going to waste my time and rap, man's just going to talk over this

Yo!

Alright, you don know, boom, let's go

Yeh, alright, yo!

Shaquille O'Neal

You think you're bad?

Cause your knees are made of steel

But you're not, you're moist

Man's see your armpit drippin'

In the changing room

Yeah, alright, cool

Uh!

They call you big Shaq

But you're not big Shaq

And your teeth bare plaque

Mine no plaque

You're just wack

Cut some slack

Look at your back

It's just black

I'm fin

I don't sing

Man heard you sing

Ring a ding ding

Phone goes ping

I ling ling

Yo!

Shabado

Look at your toenails

They're black

Mouth is white, like crack

You don't want to see me

In the lab

Man hit your head

Like slab

You dun know

Huh!

Man don't even waste my time

I don't send, you understand what I'm saying, man just got me in the booth

Fresh off the dome, yo!

The ting go skrr pa pa pa katakaka tun tun tuka tun tun

When I see man

Ku tu kun tun tun tun

Casualty

Kutukum tum tum

yeh, yeh

yeh yeh, aye Shaquille O'Neal

I'm in New York City

If you're bad come link me, mans in a hotel

But you're not going to come

You get me? Mans called big shaq

But you can't even roll by yourself, you need your body guards

I'm in-im in-im in America big man!

Come, COME LINK ME BRUV!

Say notin, I'm here

Hold tight drizzy, hold tight Busta Rhymes

Hold tight Puff Daddy

Hold tight DJ Khaled, my brudda, hold tight Cardi B

You don know the ting, bang bang

I'm gone

For more infomation >> Big Shaq — Mans Not Hot Remix (Shaquille O' Neal Diss Track) - Duration: 3:06.

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Matt Damon & Julianne Moore Answer the Web's Most Searched Questions | WIRED - Duration: 5:20.

For more infomation >> Matt Damon & Julianne Moore Answer the Web's Most Searched Questions | WIRED - Duration: 5:20.

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Stranger Things Cast Show Us the Last Thing on Their Phones | WIRED - Duration: 2:50.

For more infomation >> Stranger Things Cast Show Us the Last Thing on Their Phones | WIRED - Duration: 2:50.

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Saturday Sessions: Julien Baker performs "Televangelist" - Duration: 5:10.

For more infomation >> Saturday Sessions: Julien Baker performs "Televangelist" - Duration: 5:10.

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5:30 News ON DEMAND 10.31.17 - Duration: 9:17.

For more infomation >> 5:30 News ON DEMAND 10.31.17 - Duration: 9:17.

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10:00 News ON DEMAND: 10.31.17 - Duration: 9:18.

For more infomation >> 10:00 News ON DEMAND: 10.31.17 - Duration: 9:18.

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List of Idol Groups That Will Appear on 'The Unit'(News) - Duration: 1:18.

List of Idol Groups That Will Appear on 'The Unit'

If youre wondering whether there is anything to look forward to in the month of November, we can tell you that watching The Unit should be one of them.

 It turns out that there are more and more idol groups that are steadily jumping on to the TV show this fall and although not every member of each idol group is going to make an appearance, K-Pop fans are already excited that some of them will, and really at this point, the more the merrier.

The Unit Idol Group Lineup. SONAMOO (EuiJin). BOYFRIEND (DongHyun, JeongMin, KwangMin, MinWoo).

LABOUM (JiEn,HaeIn,YuJeong). 100% (MinWoo, RokHyeon, JongHwan, HyukJin). Boys Republic (WonJun, SunWoo, SungJoon, MinSoo, SooWoong).